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Zhuhaishi Shuangbojie Technology Co., Ltd.

Trilostane, 13647-35-3, Trilostane Powder manufacturer / supplier in China, offering Cancer Treatment Raws Trilostane CAS 13647-35-3 for Good Health, Injectable Muscle Mass Gain and Cutting Steroid Boldenone Undecylenate/ Equipoise, Anti Tumor Peptide Leuprolide Acetate 53714-56-0 and so on.

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Supplier Homepage Product Pharmaceutical Intermediates Cancer Treatment Raws Trilostane CAS 13647-35-3 for Good Health

Cancer Treatment Raws Trilostane CAS 13647-35-3 for Good Health

FOB Price: US $1 / G
Min. Order: 10 G
Min. Order FOB Price
10 G US $1/ G
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Production Capacity: 5000kgs
Transport Package: Disguised Package
Payment Terms: T/T, Western Union, Money Gram, bitcoin

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Basic Info
  • Model NO.: 13647-35-3
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: >99%
  • Appearance: Powder
  • Molecular Weight: 329.43
  • Payment: T/T, Wu, Moneygram, Bitcoin
  • Delivery Mode: Express Door to Door
  • Trademark: Shuangbojie
  • Origin: China
  • Powder: Yes
  • Certification: USP
  • State: Solid
  • CAS: 13647-35-3
  • Molecular Formula: C20h27no3
  • Einecs: 237-133-0
  • Delivery Time: Within 24 Hours
  • MOQ: 10g
  • Specification: 99% min.
  • HS Code: 3001901000
Product Description
Pharmaceutical Raws Trilostane CAS 13647-35-3 for Cancer Treatment

Product Name: Trilostane
Synonyms:    TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al;modrenal
CAS:    13647-35-3
MF:    C20H27NO3
MW:    329.43
EINECS:    237-133-0

treatment of Cushing's syndrome
Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome and primary hyperaldosteronism. These are both disorders where excess amounts of corticosteroid hormones are produced in the body. Corticosteroids are essential for the body to make use of carbohydrates, fats and proteins and for a normal response to stress. They are also necessary for the regulation of salt and water balance in the body. Trilostane helps prevent the production of corticosteroids, controlling the symptoms associated with these disorders. 
Trilostane can also be useful in the treatment of breast cancer that has relapsed in women who have gone through menopause.

Uses in dogs    
Trilostane was withdrawn from the United States market in April 1994. However, it was approved in 2008 for the treatment of Cushing's disease (hyperandrenocorticism) in dogs.
It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs.
1. has kidney or liver disease.
2. takes certain medications used to treat heart disease.
3. pregnant.
4. taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
5. had an allergic reaction to this or any other medicine.

Indications    
Trilostane can inhibit 3β-dehydrogenase in the synthesis of corticosteroids, and decrease the synthesis of cortisol and aldosterone. It also can be used in the treatment of Cushing's syndrome (hypercortisolism) and primary aldosteronism. But the efficacy to treat Cushing's syndrome (hypercortisolism) is not as metyrapone. This product also has a significant role in lowering blood testosterone levels, which may be related with that its synthesis is inhibited.

Mechanism    Breast cancer is one of hormone-dependent tumors. And estrogen is the main driving factor of the growth of breast cancer cells. Thus, one of the modern treatment of breast cancer is the major target of estrogen through inhibiting the production of estrogen or block the action of estrogen or estrogen receptor in its site of action. It has been known that estrogen receptor is only a single receptor, but recent studies have identified that there are at least two subtypes α and β. Estrogen uniting with α- estrogen can stimulate cell growth, but it uniting with β-estrogen receptor can cut α- estrogen receptors and slow the rate of cell proliferation. Research revealed that the trilostane cannot only lower the production of estrogen, but also can modulate the binding of estrogen receptors on different subtypes. And meanwhile the dual effect of α-estrogen receptor inhibitors and β-estrogen receptor appears. Finally it can block and alter the negative effect of estrogen on cancer cells. The unique mode of action of trilostane can not only set it apart from other existing anti-estrogen drugs, but also be the pharmacological basis of that it is still highly effective on breast cancer in treatment failure with other anti-estrogen therapy or resistant breast cancer.
The treatment of advanced breast cancer    Breast cancer is the most common type of tumor in women. Currently, for postmenopausal patients with hormone receptor-positive or unknown, clinical treatments unanimously recommend to be the preferred antiestrogen therapy, and the role of this therapy in delaying disease progression and improving survival time also has been affirmed and confirmed in numerous studies of breast cancer. 
Trilostane (trade name Modrenal) developed by the biotechnology company has already been on the market. It can be used for the treatment of postmenopausal women that hormone-selective cancer has spread outside the breast. The pharmaceutical uses two ways to slow down the disease progression. For hormone-sensitive breast cancer, estrogen promotes the growth of cancer cells by acting to the two receptors. Estrogen receptor α is cancer accelerator, and estrogen receptor β is the brake. Modrenal strengthens estrogen adsorption to the estrogen receptor β, and weakens the adsorption to estrogen receptor α. Meanwhile it also acts on another loci AP1in cell DNA to reduce cell proliferation.
Chemical Properties    Tan Crystals
Usage    An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer
Usage    antifungal, inhibits mitosis in metaphase

Steroid Hormone Powder:
Testosterone AcetateTrenbolone AcetateMGF
Testosterone CypionateTrenbolone EnanthatePEG MGF
Testosterone DecanoateBoldenone AcetateCJC-1295
Testosterone EnanthateBoldenone undecylenateCJC-1295 DAC
Testosterone IsocaproateBoldenone CypionatePT-141
Testosterone PhenylpropionateBoldenone PropionateMelanotan-1
Testosterone PropionateNandrolone DecanoateMelanotan-2
Testosterone UndecanoateNandrolone phenylpropionateGHRP-2
MesteroneNandrolone undecylateGHRP-6
Testosterone Sustanon 250Nandrolone cypionate Ipamorelin
Clostebol AcetateNandrolone propionateHexarelin
MethylandrostanoloneMethyltrienoloneSermorelin
Methenolone EnanthateDrostanolone PropionateOxytocin
Methenolone AcetateDrostanolone EnanthateTB500
AnadrolStanoloneFragment 176-191
AnavarTadalafilTriptorelin
WinstrolVardenafilTesamorelin
Clomifene citrateDianabolGonadorelin
Toremifene citrateTamoxifen CitrateDSIP 
FinasterideDapoxetine hydrochlorideSelank

Semi-finished Injectable / Oral steroids:
Test prop-----------100mg/ml 200mg/ml
Test enan-----------250mg/ml 300mg/ml 400mg/ml 500mg/ml 600mg/ml
Test cyp------------200mg/ml 250mg/ml 300mg/ml
Test Sustanon-------200mg/ml 250mg/ml 300mg/ml 400mg/ml
Deca----------------200mg/ml 250mg/ml
Equipoise-----------200mg/ml 300mg/ml
Tren ace------------100mg/ml 200mg/ml
Tren enan-----------100mg/ml 200mg/ml
Dianabol------------50mg/ml
Winstrol------------50mg/ml
Masteron------------100mg/ml 150mg/ml
Primobolone---------100mg/ml
Supertest-----------450mg/ml
Anomass ------------400mg/ml
Ripex---------------225mg/ml
Tritren-------------180mg/ml
Tri Test------------300mg/ml
Tri Deca------------300mg/ml
Test Blend----------450mg/ml 500mg/ml
Nandro Test---------225mg/ml
Mass----------------500mg/ml
Cut Depot-----------400mg/ml
Tren Test-----------225mg/ml
Nandro Test Depot---------450mg/ml
Equi Test-----------------450mg/ml
Rip Cut-------------------175mg/ml
Tren Test Depot-----------450mg/ml

Our advantage
1. We have experience in exporting steroids, as you know, EU places much emphasis on them, and you must find a experienced partner who will assure you;
2. Quality: Our company is a professional leading factory in China in pharmaceutical area, We had stable customers and exported to Germany, Spain, UK, USA, Australia, Middle East, and any other countries. We can provide good references about our company. As for the quality of the products, we 're sure they can satisfy you well enough;
3. Package: Professional packing with professional materials
4. Delivery: We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.
5. Service: Best Service with after-sales service and consultation
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