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Supplier Homepage Product Pharmaceutical Intermediates Medical Grade Eye Drops Raw Powder Bimatoprost (CAS 155206-00-1)

Medical Grade Eye Drops Raw Powder Bimatoprost (CAS 155206-00-1)

FOB Price: US $1 / Piece
Min. Order: 1 Piece
Min. Order FOB Price
1 Piece US $1/ Piece
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Production Capacity: 50000kg/Month
Transport Package: as for Customer′s Requirement
Payment Terms: T/T, Western Union, Money Gram

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Basic Info
  • Model NO.: 155206-00-1
  • Customized: Non-Customized
  • Suitable for: Elderly
  • Purity: >99%
  • Tb500 Payment: T/T, Western Union and Money Gram
  • Tb500 MOQ: 10vials
  • Specification: USP/BP
  • HS Code: 123456
  • Powder: Yes
  • Certification: ISO 9001
  • State: Powder
  • Tb500 CAS: 77591-33-4
  • Tb500 Delivery: Within 24hours After Your Payment
  • Trademark: Shuangbojie
  • Origin: China
Product Description
product name:Bimatoprost
Synonyms: N-ETHYL-9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z, 13E-DIEN-1-AMIDE;BIMATOPROST;BIMATOPROST(TM);17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ETHYL AMIDE;BIMATOPROST;17-phenyl-tri-norprostaglandin f2α-ethyl amide;(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
CAS: 155206-00-1
MF: C25H37NO4
MW: 415.57
Usage Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It ha
Usage Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.

Bimatoprost
ItemsSpecificationsResults
AppearanceWhite to almost white powderWhite powder
IdentificationHPLC retention time of sample complies with that of known sampleComplies
Specific rotation[a]D20: +33.0°~+37.0°(C=1.0,CH3CN)+36.0°
Water≤1.0%0.31%
Related substances15R-Bimatoprost: ≤0.30%
Bimatoprostfree acid: ≤0.10%
5,6-trans-Bimatoprost: ≤0.50%
Any other single impurity: ≤0.10%
Total other impurities: ≤ 0.50%
Not detected
Not detected
0.07%
0.05%
0.18%
Residual solventsTer-Butylmethyl ether: ≤ 5000ppm
Ethanol: ≤5000ppm
N-Hexane: ≤ 290ppm
Ethyl acetate: ≤5000ppm
Not detected
Not detected
16.13ppm
18.92ppm
Purity≥99.5%99.82%

Bimatoprost is a powder, which is very soluble in ethyl alcohol and methyl alcohol and slightly soluble in water. Treating increased pressure in the eye (ocular hypertension) and open-angle glaucoma.
Its chemical name is (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-N-ethyl-5-heptenamide, and its molecular weight is 415.58. Its molecular formula is C25H37NO4. Its chemical structure is:
 
Bimatoprost drops are a prostaglandin analog. It works to lower pressure in the eye by increasing fluid drainage from the eye.
Bimatoprost ophthalmic solution
0.03% is indicated to treat hypotrichosis of the eyelashes by increasing their growth including length, thickness and darkness. 
Clinical Pharmacology
Mechanism of Action
Bimatoprost is a structural prostaglandin analog. Although the precise mechanism of action is unknown the growth of eyelashes is believed to occur by increasing the percent of hairs in, and the duration of the anagen or growth phase.
Absorption
After one drop of bimatoprost ophthalmic solution 0.03% was administered once daily into both eyes (cornea and/or conjunctival sac) of 15 healthy subjects for two weeks, blood concentrations peaked within 10 minutes after dosing and were below the lower limit of detection (0.025 ng/mL) in most subjects within 1.5 hours after dosing. Mean Cmax and AUC0-24hr values were similar on days 7 and 14 at approximately 0.08 ng/mL and 0.09 ng•hr/mL, respectively, indicating that steady state was reached during the first week of ocular dosing. There was no significant systemic drug accumulation over time.
Distribution
Bimatoprost is moderately distributed into body tissues with a steady-state volume of distribution of 0.67 L/kg. In human blood, bimatoprost resides mainly in the plasma. Approximately 12% of bimatoprost remains unbound in human plasma.
Metabolism
Bimatoprost is the major circulating species in the blood once it reaches the systemic circulation. Bimatoprost then undergoes oxidation, N-deethylation, and glucuronidation to form a diverse variety of metabolites.
Elimination
Following an intravenous dose of radiolabeled bimatoprost (3.12 mcg/kg) to six healthy subjects, the maximum blood concentration of unchanged drug was 12.2 ng/mL and decreased rapidly with an elimination half-life of approximately 45 minutes. The total blood clearance of bimatoprost was 1.5 L/hr/kg. Up to 67% of the administered dose was excreted in the urine while 25% of the dose was recovered in the feces.

Thymosin Beta-4 Acetate Safe Package Fast Delivery TB-500
 Specification : 2mg/5mg/10mg
 Appearance : White powder
Formulations : Sterile Filtered white lyophilized (Freeze-Dried)
Purity : 99% 
 Specification : 2mg/vial 1g/bags
 Appearance : White Lyophilized Powder 
 Place of Origin : China 
 Standard : USP 
Certification : SGS 
Method of Analysis : HPLC 
Product Usage : This product is intended as a research chemical only. 
 
Brief Introduction:
1. One of TB-500 key mechanisms of action is its ability to regulate the cell-building protein, Actin, 
a vital component of cell structure and movement. Of the thousands of proteins present in cells, 
actin represents up to 10% of the total proteins which therefore plays a major role in the genetic 
makeup of the cell.
 
2. This potent peptide is a member of a ubiquitous family of 16 related molecules with a 
high 
conservation of sequence and localization in most tissues and circulating cells in the body. 
TB-500 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule in eukaryotic cells.
 
3. TB-500 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells.
 
4. An additional key factor of TB-500 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.
 
5. Research confirms that TB-500 is a potent, naturally occurring wound repair factor with anti-inflammatory properties. TB-500 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues.
HOW TO USE: Give one 2ml vial subcutaneous each week for six consecutive weeks. There after use one 2ml vial per month. It's best to give injection 6 days before intense work.
 
6. We recommend giving the shot the day after intense work then giving the shot every seven day there after. You must make sure to hydrate very well when using this product. Give normal vitamins and minerals to support normal racing function. Hydration is key when using this product.
 
Applications:
1. Increases Red Blood Cells
2. Stops bleeding
3. Increase Endurance
4. Reduces Tie Up
5. Helps breathing
6. Reduces stomach acid which eliminates ulcers
7. Increases lean muscle mass
8. Helps repair tendons and ligaments
9. Endothelial (blood vessels) cell differentiation (increases red blood cells)
  Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues
 
Keratinocyte migration Collagen deposition; and Decreases inflammation.
One of T4 key mechanisms of action is its ability to regulate the cell-building protein, Actin, a vital component of cell structure and movement. Of the thousands of proteins present in cells, actin represents up to 10% of the total proteins which therefore plays a major role in the genetic makeup of the cell.
This potent peptide is a member of a ubiquitous family of 16 related molecules with a high conservation of
sequence and localization in most tissues and circulating cells in the body. T4 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule in eukaryotic cells.
T4 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells.
An additional key factor of T4 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.
Research confirms that T4 is a potent, naturally occurring wound repair factor with anti-inflammatory properties. T4 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues.
How to use?
Give one 2ml vial subcutaneous each week for six consecutive weeks. There after use one 2ml vial per 
month. It's best to give injection 6 days before intense work.
 
Specification:

CAS No.

77591-33-4 

Molecular Formula

C212H350N56O78S 

Molecular Weight

4963.49 

Purity (HPLC)

98%min

Mass Balance

95.0~105.0%

Single Impurity (HPLC)

2.0%max 

Amino Acid Composition

10% of theoretical 

Peptide Content (N%)

 80.0%

Water Content(Karl Fischer)

 5.0% 

Acetate Content (HPIC)

15.0% 

MS(ESI)

Consistent 

Products Customization:
1.0.5mg CJC with DAC + 0.5mg 
2.Hexarelin + 1mg ipamorelin
3.Ghrp-6  1mg+Ipamorelin 
4.1mg+Cjc-12951mg+MGf 500mcg
We can mix different polypeptides according to your requirement.

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T-A003CJC-1295 with DAC2mg/vial
T-A004CJC-1295 without DAC2mg/vial
T-A005PT-14110mg/vial
T-A006MT-110mg/vial
T-A007MT-210mg/vial
T-A008GHRP-25mg/vial
T-A009GHRP-210mg/vial
T-A010GHRP-65mg/vial
T-A011GHRP-610mg/vial
T-A012Ipamorelin2mg/vial
T-A013Hexarelin2mg/vial
T-A014Sermorelin2mg/vial
T-A015Oxytocin1g, 2mg/vial
T-A016TB5002mg/vial
T-A017pentadecapeptide BPC 1572mg/vial
T-A018
 
2mg/vial
T-A019Triptorelin2mg/vial
T-A020Tesamorelin2mg/vial
T-A021Gonadorelin2mg/vial
T-A022Gonadorelin10mg/vial
T-A023DSIP2mg/vial
T-A024Selank5mg/vial

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4,We have the best customer service and excellent shipment ability. Contact us to have a full list of our products and price list.
5,Besides raw steroid powder and liquid,we offer hormone solution and formula.We can teach you how to make hormone solution on the site. Any visit to our lab is welcomed.
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