USP Highest Pure Anastrozole Arimidex (120511-73-1) for Anti Estrogen Breast Cancer
|FOB Price:||US $1.2 / gram|
|Min. Order:||10 grams|
|Min. Order||FOB Price|
|10 grams||US $1.2/ gram|
|Production Capacity:||4, 800kg/Month|
|Transport Package:||Professional and Super Discreet|
|Payment Terms:||T/T, Western Union, Paypal, Money Gram, Bitcoin|
- Model NO.: CAS 120511-73-1
- CAS: 120511-73-1
- Purity: 99.80% USP32
- Advantages: 14 Years Old Manufacturer / Lowest Price
- Lead Time: Prompt After Payment Confirmed
- Trademark: Shuangbojie
- Origin: China
- Product Name: Anastro Zole/ Arimidex
- Appearance: White Crystalline Powder
- Use: an Aromatase Inhibitor/Antineopla/Breast Cancer
- Stock: Mass and Plenty (Sample Available)
- Shipping: Average 6.5 Days / Door-to-Door
- Specification: USP/BP/EP
- HS Code: 3001200020
Attention: China 14 years old Manufacturer direct selling; Gold Member, Gold Quality; Lowest price served; Mass and plenty in stock now ; Sample and COA are available at any time; Prompt shipment after payment confirmed; Re-send policy; Door-to-Door; 5% discount for second same order.
|Product Name||Anastro zole/ Arimidex|
|Product Categories||Active Pharmaceutical Ingredients;Antineoplastic;All Inhibitors;anti-neoplastic;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Anastrozole;API|
|Appearance||White crystalline powder|
|Biological Activity||Potent and highly selective aromatase (CYP19) inhibitor (IC 50 = 15nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo . Orally active.|
|Usage||An aromatase inhibitor. Used as an antineoplastic.|
Description and Application:
Anastrozole (INN) is a non-steroidal aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women. The severity of breast cancer can be increased by estrogen, as sex hormones cause hyperplasia, and differentiation at estrogen receptor sites. Anastrozole works by inhibiting the synthesis of estrogen. The patent on Arimidex by AstraZeneca expired June 2010.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.
Potent selective triazole aromatase inhibitors, can inhibit the cytochrome P-450 aromatase enzyme which depends blocking the biosynthesis of estrogen, and estrogen to stimulate breast cancer cell growth factors. Treatment of breast cancer, especially for those with hormone relapse after adjuvant therapy after menopause for women with advanced breast cancer.
Arimidex is the aromatase inhibitor of choice. Arimidex's mechanism of action - blocking conversion of aromatizable steroids to estrogen - is in contrast to the mechanism of action of anti-estrogens such as clomiphene (Clomid) (Nolvadex), which block estrogen receptors in some tissues, and activate estrogen receptors in others.
The ATAC trial was an international randomised controlled trial of 9366 women with localized breast cancer who received either anastrozole, tamoxifen, or both for five years, followed by five years of follow-up. After more than 5 years the group that received anastrozole had significantly better clinical results than the tamoxifen group. The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized breast cancer, which is estrogen receptor (ER) positive. Another study found that the risk of recurrence was reduced 40%, but was associated with an increased risk of bone fractures. The study concluded that ER positive patients benefited from switching from tamoxifen to anastrozole in patients who have completed 2 years' adjuvant tamoxifen. A more recent trial found that anastrozole significantly reduced the incidence of breast cancer in postmenopausal women relative to placebo, and while there were side effects related to estrogen deprivation observed, the researchers concluded that this was probably not related to the treatment. Lead author Jack Cuzick was quoted by the BBC as saying, "This class of drugs is more effective than previous drugs such as tamoxifen and crucially, it has fewer side effects," adding that he thought there was now enough evidence to support offering the drug.
COA and Specifications:
|Product||Anastro zole/ Arimidex|
|Description||White crystalline powder||Complies|
|Conform with standard IR|
Conform with standard HPLC
|Solubility||Freely soluble in methanol,acetone,|
ethanol and tetrahydrofuran.
And very soluble in acetonitrile
|Total Unspecified Impurity||max. 0.2%||0.08%|
|Individual unspecified impurlty||max. 0.1%||0.05%|
|Related compound B||max. 0.2%||0.07%|
|Related compound C||max. 0.2%||0.04%|
|Related compound D||max. 0.1%||0.05%|
|Related compound E||max. 0.1%||0.06%|
|Limit of cyclohexane||max. 0.08%||ND|
|Limit of ethylacetate||max. 0.1%||0.07%|
|Residue on ignition||max. 0.1%||0.07%|
|Storage||Cool and dry|
|Conclusion||It complies to USP32 .|
Packaging & Delivery Service:
1.Sufficient stock, to delivery promptly at the very day when receive the payment
2.Sophisticated and professional logistic agent.
3.Well-trained and disciplined packing team. Unique ways to ship goods to your destination. Fast and discreet shipment could be arranged for customs pass Guaranteed.
4.Packing pictures and tacking code are provided within 12 hours after receiving the payment. Updated tracking information will be provided every other day.
5.After-sale service: Any questions or problems after receiving the product, please feel free to contact us. Problems would be solved immediately.
1. Quality guarantee: we are a leading professional factory in China special in pharmaceuticals (featured anesthetics, steriods, and peptides) for more than 14 years. Our product sexported to all over the world.
2. Discreet packing: The best-suited package would be selected to pass customs 100% guaranteed. The package updates would be closely tracked and timely informed. Once any problem found, the package would be reshipped for you.
3. Alternative delivery ways: by land, by air, by sea, by express(FedEx,UPS,DHL,EMS etc.). The most cost-effecient forwarder would be recommanded.
4. Considerate after-service: 24/7 at service for you. Any problem would be valued and solved ASAP.
5. COA (by HPLC) and sample are available at any time.
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Words to friend(from Joy):
| We are a leading chemical factory founded in 2001, have been in this line for 14 years. All of our staff will strive every effort to serve you Best Quality and Lowest Price. Wherever you are from, whoever you are, you are my valued and my God. So if you have any interest or need, pls come to me freely. You can email me or sky-pe me at joy.peng18 or just call me directly. You know, Joy is always and always here at your service. |
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