Treatment Pharmaceutical Raw Material Isotretinoin (CAS 4759-48-2)
|FOB Price:||US $1 / Piece|
|Min. Order:||1 Piece|
|Min. Order||FOB Price|
|1 Piece||US $1/ Piece|
|Transport Package:||as for Customer′s Requirement|
|Payment Terms:||T/T, Western Union, Money Gram|
- Model NO.: 4759-48-2
- Customized: Non-Customized
- Suitable for: Elderly
- Purity: >99%
- Payment: T/T, Western Union and Money Gram
- Product Name: Isotretinoin
- Mf: C20h28o2
- Einecs: 225-296-0
- Appearance: Orange Crystal Powder
- Specification: USP/BP
- HS Code: 123456
- Powder: Yes
- Certification: USP
- State: Powder
- MOQ: 100g
- Delivery: Within 24hours After Your Payment
- CAS: 4759-48-2
- MW: 300.44
- Assay: 99%
- Trademark: Shuangbojie
- Origin: China
Appearance: Orange Crystal Powder
Chemical Property: The melting point of 174 ~ 175 Centigrade. UV maximum absorption: 354nm ( 39800). Acute toxicity of LD50 (20 days) mice, rats by intraperitoneal injection of:904901 (mg/kg); 3389 > 4000 oral.
Usage of Tretinoin:
Isotretinoin or 13-cis retinoic acid is a very effective medication for the treatment of acne . It is a retinoid; this means it is derived from vitamin-A (retinoic acid). The liver naturally makes small quantities of isotretinoin from vitamin-A, but the drug we prescribe is made synthetically.
Certificate Of Analysis for Isotretinoin:
|Name of Product||ISOTRETINOIN|
|Manufacturing Date||2012.10.16||Expiry Date||2014.10.16|
|Description||Yellow crystalline powder||complies|
|The IR absorption spectrum should correspond||complies|
|Should exhibits maximum absorption at 354nm||complies|
|Loss on drying||≤0.5%||0.07%|
|Residue on ignition||≤0.1%||0.02%|
|Conclusion||The product complies with USP34|
Due to sideeffects and high cost, isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments. Acne treatment usually begins with topical medications (e.g., benzoyl peroxide and adapalene), followed by oral antibiotics and isotretinoin as a last resort.
Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments Acne treatment usually begins with topical retinoids (e.g., tretinoin, adapalene), in combination with topical antibiotics (e.g., erythromycin) or antiseptics (e.g., benzoyl peroxide-containing preparations), followed by oral antibiotics In women a cyproterone acetate-containing contraceptive pill can be useful if there are no contraindications.
In cases of hormonal acne, such as in women in their 20s and 30s with cyclical acne, often a course of isotretinoin can permanently improve acne obviating the need for lifelong hormonal manipulation.
Isotretinoin's main indication is for the treatment of severe cystic acne vulgaris.Many dermatologists also support its use for treatment of lesser degrees of acne that prove resistant to other treatments, or that produce physical or psychological scarring.
It is also somewhat effective for hidradenitis suppurativa and some cases of severe acne rosacea. It can also be used to help treat harlequin ichthyosis, lamellar ichthyosis and is used in xeroderma pigmentosum cases to relieve keratoses. Isotretinoin has been used to treat the extremely rare condition fibrodysplasia ossificans progressiva. It is also used for treatment of neuroblastoma, a form of nerve cancer.
Isotretinoin therapy has furthermore proven effective against genital warts in experimental use, but is rarely used due to potentially severe side effects. In a small-scale study, low dose oral isotretinoin showed considerable efficacy; Isotretinoin may represent an efficacious and safe alternative systemic form of therapy for RCA of the cervix. Yet, albeit this indicative evidence not many studies have been conducted to further confirm its effectivenes. In most countries this therapy is currently unapproved and only used if other therapies failed.
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