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Zhuhaishi Shuangbojie Technology Co., Ltd.

Trilostane, Arimidex, Clomifene Citrate manufacturer / supplier in China, offering 99% Pharmaceutical Raw Powder Trilostane for Breast Cancer (13647-35-3), 1mg/Vial Freeze-Dried Powder Peptide Gdf-8 for Improve Muscle Mass, Healthy Pharmaceutical Raw Material Tadalafil for Erectile Dysfunction CAS 65-19-0 and so on.

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Supplier Homepage Product Anticancer Powder 99% Pharmaceutical Raw Powder Trilostane for Breast Cancer (13647-35-3)

99% Pharmaceutical Raw Powder Trilostane for Breast Cancer (13647-35-3)

Purchase Qty.:
(grams)
10-99 100+
FOB Unit Price: US $1 US $10
Purchase Qty. (grams) FOB Unit Price
10-99 US $1
100+ US $10
Get Latest Price
Production Capacity: 100kg/Month
Transport Package: Foil Bag
Payment Terms: T/T, Western Union, Paypal, Money Gram, Bitcoin

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Basic Info
  • Model NO.: 13647-35-3
  • Customized: Non-Customized
  • Suitable for: Elderly, Children, Adult
  • Purity: >99%
  • Mf: C20h27no3
  • Einecs: 237-133-0
  • Shipping Method: EMS, TNT, FedEx, UPS, Sea Freight
  • Specification: ISO9001
  • HS Code: 3002909099
  • Powder: Yes
  • Certification: GMP, HSE, ISO 9001, USP, BP
  • State: Solid
  • Appearance: White Powder
  • MW: 329.43
  • Delivery Time: 1-2work Days
  • Trademark: Shuangbojie
  • Origin: China
Product Description
99% Pharmaceutical Raw Powder Trilostane for Breast Cancer ( 13647-35-3 )

A) Trilostane Details

Name: Trilostane
Synonyms: (2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril
CAS: 13647-35-3
MF: C20H27NO3
MW: 329.43
EINECS: 237-133-0
Chemical Properties: Tan Crystals
Usage: An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer. antifungal, inhibits mitosis in metaphase .
Packing:As required

B) Trilostane COA:
 
Test Items Specification Test Results
 Appearance white oralmost white,crystalline powder Conform
 Solubility Freely soluble in water,practically insoluble or very slightly soluble in alcohol and
 in methylene chloride.
 Conform
 Identification A The UV absorption spectrum of the sample shows 
an absorption maximum at 276nm.The specific 
absorbance at the Maximum is55 to 64.
 Conform
  B Infraed absorption spectrophotometry. Conform
  C Chromatogram obtained with test solution (b) is 
similar in position color & size to the principal spot in the chromatogram obtained 
with the reference solution.
 Conform
  D An orange-red color develop in methylene chloride layer. Conform
  E It geves reaction (a) of sulphates. Conform
 Appearance of solution Solution S is clear and not more intensely coloured than reference solution in BY6. Conform
 Optical rotation negative 0.10° to +0.10°determined on solution S. +0.01°
 Acidity or alkalinity NMT 0.4ml of 0.01M HCL is required to change the color
 of the indicator to red.
 Conform
 Related substances Impurity J ≤0.20% Conform
  Any other impurity ≤0.30% Conform
  Total impurity ≤1.0% Conform
 Boron ≤50ppm Conform
 Sulphated ash ≤0.10% 0.06%
 Loss on drying ≤0.5% 0.30%
 Assay(on dried basis) 98.0~101.0% 99.5%

C) The Treatment of Advanced Breast Cancer

Breast cancer is the most common type of tumor in women. Currently, for postmenopausal patients with hormone receptor-positive or unknown, clinical treatments unanimously recommend to be the preferred antiestrogen therapy, and the role of this therapy in delaying disease progression and improving survival time also has been affirmed and confirmed in numerous studies of breast cancer.
Trilostane (trade name Modrenal) developed by the biotechnology company has already been on the market. It can be used for the treatment of postmenopausal women that hormone-selective cancer has spread outside the breast. The pharmaceutical uses two ways to slow down the disease progression. For hormone-sensitive breast cancer, estrogen promotes the growth of cancer cells by acting to the two receptors. Estrogen receptor α is cancer accelerator, and estrogen receptor β is the brake. Modrenal strengthens estrogen adsorption to the estrogen receptor β, and weakens the adsorption to estrogen receptor α. Meanwhile it also acts on another loci AP1in cell DNA to reduce cell proliferation.

D) Mechanism

Breast cancer is one of hormone-dependent tumors. And estrogen is the main driving factor of the growth of breast cancer cells. Thus, one of the modern treatment of breast cancer is the major target of estrogen through inhibiting the production of estrogen or block the action of estrogen or estrogen receptor in its site of action. It has been known that estrogen receptor is only a single receptor, but recent studies have identified that there are at least two subtypes α and β. Estrogen uniting with α- estrogen can stimulate cell growth, but it uniting with β-estrogen receptor can cut α- estrogen receptors and slow the rate of cell proliferation. Research revealed that the trilostane cannot only lower the production of estrogen, but also can modulate the binding of estrogen receptors on different subtypes. And meanwhile the dual effect of α-estrogen receptor inhibitors and β-estrogen receptor appears. Finally it can block and alter the negative effect of estrogen on cancer cells. The unique mode of action of trilostane can not only set it apart from other existing anti-estrogen drugs, but also be the pharmacological basis of that it is still highly effective on breast cancer in treatment failure with other anti-estrogen therapy or resistant breast cancer.

E) Our Advantages:

a, We are the manufacturer of all kinds of powders. We focus on providing customers with high quality products, competitive price, best service and timely delivery.
b, Price: Please let us know the quantity you required, because for small order and bulk purchase, the price will be difference.  
c, Shipping items: Shipping items will be delivered by international express like EMS, TNT, UPS, FEDEX or DHL after receiving received. Every item will be shipped out in 2-3 working days after the payment is done. The product usually arrives in 1-4 days based on the different destination, and online track is provided.

F) Recommend Steroid Powder
 
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Sustanon 250--
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