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Megestrol Acetate, Pharmaceutical Intermediates, Steroid manufacturer / supplier in China, offering Raw Steroid Powder Progestogen Megestrol Acetate for Women 595-33-5, Raw Lyophilized Powder Polypeptide Ghrp-6 5mg/Vial, Proscar Direct Sale Steroid Powder Finasteride (Propecia) 98319-26-7 and so on.

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Supplier Homepage Product Female Hormone powder Raw Steroid Powder Progestogen Megestrol Acetate for Women 595-33-5

Raw Steroid Powder Progestogen Megestrol Acetate for Women 595-33-5

Purchase Qty.:
(g)
10-99 100+
FOB Unit Price: US $1 US $2
Purchase Qty. (g) FOB Unit Price
10-99 US $1
100+ US $2
Get Latest Price
Production Capacity: 50000kg/Month
Transport Package: Foil Bag or Tin
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: 595-33-5
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: >99%
  • Einecs: 209-864-5
  • Mf: C24h32o4
  • Appearance: White or Light Yellow Crystalline Powder
  • Delivery Time: Within 24 Hours After Confirm Your Payment
  • Export Markets: Global
  • Specification: Enterprise standard
  • HS Code: 123456
  • Powder: Yes
  • Certification: ISO 9001, USP
  • State: Solid
  • CAS: 595-33-5
  • Assay: 99%
  • MW: 384.51
  • Payment: Western Union, Moneygram, T/T, Bitcoin
  • Express: UPS, TNT, DHL, EMS, Hkems, FedEx
  • Trademark: Shuangbojie
  • Origin: China
Product Description
Raw Steroid Powder Progestogen Megestrol Acetate for Women 595-33-5

Megestrol acetate
English Synonyms: 17-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione;
17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione;17-alpha-acetoxy-6-dehydro-6-methylprogesterone;17alpha-Acetoxy-6-dehydro-6-methylprogesterone;17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione17-acetate;5071;6-dehydro-6-methyl-17-alpha-acetoxyprogesterone;6-Dehydro-6-methyl-17alpha-acetoxyprogesterone
CAS NO.: 595-33-5
EINECS: 209-864-5
Assay: 99%
Molecular Formula:C24H32O4
Molecular Weight:384.51
Packing:5kg/tin,1KG/foil bag or  as required
Appearance: White or light yellow crystalline powder (methanol), odorless and tasteless.
Melting point 214-216. Soluble in acetone, slightly soluble in ethanol, einsoluble in water
Usage:1). Mainly used for short-acting oral contraceptives, also can be used for intramuscular injection of long-acting contraceptives.
2). For the treatment of dysmenorrhea, amenorrhea, dysfunctional uterine bleeding, endometriosis and endometrial adenocarcinoma

Product Description:
Megestrol acetate (INN, USAN, BAN, JAN) (abbreviated as MGA or MA, and sold mainly under the brand names Megace and Megace ES), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.
 
Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound.

Megestrol acetate has powerful antiandrogenic and antiestrogenic effects in humans at sufficient doses, capable of decreasing circulating androgen and estrogen concentrations to castrate levels in both sexes and significantly lowering the expression of the androgen receptor (AR) and the estrogen receptor (ER) in the body; as an example, one study in men with benign prostatic hyperplasia who were treated with 120-160 mg of megestrol acetate per day for 3 to 11 days found average decreases in AR quantity of 73% and 86% in the cytoplasm and nucleus of prostatic cells, respectively.[12] These actions are likely the result of a strong activation of the PR, which suppresses the secretion of the gonadotropins-peptide hormones responsible for signaling the body to produce not only progesterone but also the androgens and the estrogens-from the pituitary gland as a form of negative feedback inhibition, and hence downregulates the hypothalamic-pituitary-gonadal (HPG) axis, resulting in decreased levels of the sex hormones and their associated enzymes, carriers (e.g., sex hormone-binding globulin), and receptors.[14] It is the antiandrogenic and antiestrogenic effects of megestrol acetate mediated by suppression of the HPG axis that are believed to be largely responsible for its beneficial effects against androgen and estrogen-sensitive cancers, respectively.

Uses:
Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers. When given in relatively high doses, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia. It is also used as a contraceptive in combination with an estrogen at relatively low doses.
 
In addition to its use in humans, megestrol acetate has been used extensively in veterinary medicine in the treatment of medical conditions in cats and dogs.

Side effects:The most common side effect of megestrol acetate is weight gain. Other side effects may include nausea, vomiting, nightmares, impotence, edema, breakthrough bleeding, and shortness of breath. Rare and more severe side effects may include thrombophlebitis and pulmonary embolism.It may also cause glucocorticoid-related adverse effects such as adrenal insufficiency in some individuals and/or cases (especially if the medication is suddenly discontinued following prolonged use).

Megestrol acetate COA:
Test ItemsSpecificationTest Results
AppearanceWhite to creamy white crystalline powderWhite crystalline powder
IdentificationIRComplies
Completeness of solutionMeets the requirements.500mg beingComplies
 dissolved in 10ml of acetone 
SolubilityInsoluble in water, sparingly soluble inComplies
 alcohol. Slightly soluble in ether and in 
 fixed oils, soluble in acetone; very soluble 
 in chloroform. 
Melting range213ºC~220ºC217ºC
Specific optical rotation+8.8°~ +12.0°+11.6°
Water≤0.5%0.1%
Residue roration≤0.2%0.06
Heavy metals≤0.002%Complies
Assay97.0%~103.0%99.6%
Residual solventsMethanol≤1000ppm74ppm
 Ethanol≤1000ppm39ppm
 Methylene chloride≤500ppm28ppm
 Tetrahydrofuran≤300ppmND
 Benzene≤2ppmND

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Megestrol acetate            CAS.: 595-33-5

Our advantages:
1). Quality assurance
With our years of experience, advanced technology and continuous research, our quality is to fully meet the needs of the market to meet the requirements of customers, many customers use our products, we believe that the product is very good. Whether it is a powder, or liquid, yes, we all know, our liquid better.

2). Safe transportation
Our mode of transport is taken according to each country's situation is different transportation, while our packaging, according to the latest customs situation, constantly updated, improved our packaging, we guarantee that you receive it within 3-5 to your product.

3). The product diversity
Our products are powders and liquids, yes, brothers, the effect of the liquid is very good, but many people do not use liquid, so you are very lucky, you buy our powder, we can tell you the method of making the liquid If you buy a liquid, we will tell you how to filter. We absolutely guarantee that you can very safely use our products
 
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Vardenafil 224789-15-5Avanafil 330784-47-9
Acetildenafil 831217-01-7 Dutasteride (Avodart)  164656-23-9 
Finasteride 98319-26-7 Jinyang base
Sexual Enhancement IngredientsCrepis base 
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